This study aims to investigate the occurrence, distribution and risk assessment of volatile organic compounds (VOCs) in Dongjiang Lake of China. Twenty two kinds of VOCs were detected, and the major VOCs were alkene compounds. The total concentration of VOCs (∑VOCs) ranged from 2.93 to 4.69 µg/L, and none of the VOCs detected in Dongjiang Lake exceeded the concentration limits set in the National Drinking Water Quality Standards (GB5749-2006) or the National Environmental Quality Standards for Surface Water (GB3838-2002) of China. Risk quotients (RQ) model, Multimedia Environment Pollutant Assessment System (MEPAS) and value of odor hazard index (OHI) were used to assess the ecological risk, lifetime carcinogenic risk and olfactory risk of VOCs in Dongjiang Lake, respectively. The RQ_total values varied from 3.95 × 10⁻³ to 0.34 and the RQ values for all the 22 detected VOCs in 12 sample locations of Dongjiang Lake were below 0.01, which means negligible risk to aquatic organisms. The cancerous and non-cancerous risk indices were in the range of 2.31 × 10⁻⁹–5.16 × 10⁻⁷ and 1.68 × 10⁻⁷–1.45 × 10⁻², respectively. Bromodichloromethane and 1,1-dichloroethene were associated with the highest and lowest carcinogenic risks in all 12 sample locations. Results also demonstrated that the olfactory risk in Dongjiang Lake is negligible. These data suggest that the VOCs in Dongjiang Lake may not lead great ecological and health risks for organism and human.