The National Toxicology Program (NTP) conducted two-year studies of cell phone radiation in rats and mice exposed to CDMA- or GSM-modulated radiofrequency radiation (RFR) at exposure intensities in the brain of rats that were similar to or only slightly higher than potential, localized human exposures from cell phones held next to the head. This study was designed to test the (null) hypothesis that cell phone radiation at non-thermal exposure intensities could not cause adverse health effects, and to provide dose-response data for any detected toxic or carcinogenic effects. Partial findings released from that study showed significantly increased incidences and/or trends for gliomas and glial cell hyperplasias in the brain and schwannomas and Schwann cell hyperplasias in the heart of exposed male rats. These results, as well as the findings of significantly increased DNA damage (strand breaks) in the brains of exposed rats and mice, reduced pup birth weights when pregnant dams were exposed to GSM- or CDMA-modulated RFR, and the induction of cardiomyopathy of the right ventricle in male and female rats clearly demonstrate that the null hypothesis has been disproved. The NTP findings are most important because the International Agency for Research on Cancer (IARC) classified RFR as a “possible human carcinogen” based largely on increased risks of gliomas and acoustic neuromas (which are Schwann cell tumors on the acoustic nerve) among long term users of cell phones. The concordance between rats and humans in cell type affected by RFR strengthens the animal-to-human association. This commentary addresses several unfounded criticisms about the design and results of the NTP study that have been promoted to minimize the utility of the experimental data on RFR for assessing human health risks. In contrast to those criticisms, an expert peer-review panel recently concluded that the NTP studies were well designed, and that the results demonstrated that both GSM- and CDMA-modulated RFR were carcinogenic to the heart (schwannomas) and brain (gliomas) of male rats.

美国国家毒理学计划（NTP）对大鼠和老鼠进行了为期两年的手机辐射研究，这些老鼠和老鼠暴露于CDMA或GSM调制的射频辐射（RFR），且老鼠的大脑暴露强度类似于或仅略高于潜在的局部人体暴露于头部旁边的手机。这项研究旨在测试（零）假设，即非热暴露强度下的手机辐射不会对健康造成不利影响，并为检测到的任何毒性或致癌作用提供剂量反应数据。该研究发表的部分发现表明，暴露于雄性大鼠心脏的神经胶质瘤和神经胶质细胞增生的发生率和/或趋势显着增加，神经鞘瘤和雪旺氏细胞增生的发生率和/或趋势显着增加。这些结果，以及暴露的大鼠和小鼠的大脑中DNA损伤（链断裂）显着增加，怀孕大坝暴露于GSM或CDMA调制的RFR下时幼崽出生体重降低以及诱发右心室心肌病的发现在雄性和雌性大鼠中的研究清楚地证明了原假设已被证明。NTP的发现是最重要的，因为国际癌症研究机构（IARC）长期将RFR归类为“可能的人类致癌物”，主要是由于长期以来神经胶质瘤和听神经瘤（听神经上的雪旺细胞瘤）的风险增加手机用户。在受RFR影响的细胞类型中，大鼠与人类之间的一致性增强了动物与人类之间的联系。该评论解决了对NTP研究的设计和结果的一些毫无根据的批评，这些批评已被推广以最小化RFR实验数据在评估人类健康风险中的效用。与这些批评相反，专家同行评审小组最近得出结论，NTP研究设计合理，结果表明GSM和CDMA调制的RFR均对心脏（神经鞘瘤）和大脑（神经胶质瘤）致癌。雄性大鼠。