A new non‐enzymatic glucose sensor based gold nanoparticle (AuNp)‐chitosan (Ch/AuNp) was developed in this study. Gold nanoparticles were synthesized by using the green synthesis method, in which chitosan is used as both reducing and stabilizing agent. Gold nanoparticle surfaces were modified with different molecular agents (4‐mercaptophenyl boronic acid,MPB, and 1‐decanethiol,DT) being sensitive to glucose. Modified gold nanoparticles were immobilized to electrode surfaces and used for the glucose measurements by the potentiometric method. The best working conditions were determined for the glucose measurements. It was found that linear working range is 0.5–30 mM, while limit of detection is 0.3 mM for the glucose measurement of the prepared non‐enzymatic sensor. It was stated that the prepared sensor could be used at least 6 times and glucose response decreased approximately 10.97 % when it is waited for 30 days. Interference effect of some molecules for glucose measurement was investigated and usability of developed sensor was tested in human blood serum.

中文翻译：

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基于硼酸-二醇识别的葡萄糖选择性非酶电位壳聚糖-金纳米颗粒纳米复合传感器

在这项研究中开发了一种新的基于非酶葡萄糖传感器的金纳米颗粒（AuNp）-壳聚糖（Ch / AuNp）。通过绿色合成方法合成了金纳米颗粒，其中壳聚糖同时用作还原剂和稳定剂。用对葡萄糖敏感的不同分子试剂（4-巯基苯基硼酸，MPB和1-癸硫醇，DT）修饰了金纳米颗粒的表面。将修饰的金纳米颗粒固定在电极表面上，并通过电位法用于葡萄糖测量。确定了最佳的葡萄糖测量工作条件。发现线性工作范围为0.5–30 mM，而准备好的非酶传感器的葡萄糖测量的检出限为0.3 mM。据指出，准备的传感器至少可以使用6次，等待30天后，葡萄糖响应下降约10.97％。研究了某些分子对葡萄糖测量的干扰作用，并测试了开发的传感器在人血清中的可用性。