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Shape-Transformable, Fusible Rodlike Swimming Liquid Metal Nanomachine
ACS Nano ( IF 17.1 ) Pub Date : 2018-09-19 00:00:00 , DOI: 10.1021/acsnano.8b05203
Daolin Wang 1 , Changyong Gao 1 , Wei Wang 1 , Mengmeng Sun 1 , Bin Guo 1 , Hui Xie 1 , Qiang He 1
Affiliation  

The T-1000 liquid metal terminator, which can transform and self-repair, represents a dream for decades that robots can fundamentally change our daily life. Until now, some large-scale liquid metal machines have been developed. However, there is no report on nanoscaled liquid metal machines and their biomedical applications. We describe here a shape-transformable and fusible rodlike swimming liquid metal nanomachine, based on the biocompatible and transformable liquid metal gallium. These nanomachines were prepared by a pressure-filter-template technology, and the diameter and length could be controlled by adjusting the nanoporous templates, filter time, and pressure. The as-prepared liquid gallium nanomotors display a core–shell nanorod structure composed of a liquid gallium core and solid gallium oxide shell. Upon exposure to an ultrasound field, the generated acoustic radiation force in the levitation plane can propel them to move autonomously. The liquid metal nanomachine can actively seek cancer cells and transform from a rod to a droplet after drilling into cells owing to the removal of gallium oxide layers in the acidic endosomes. These transformed nanomachines could fuse together inside cells and photothermally kill cancer cells under illumination of near-infrared light. Such acoustically propelled shape-transformable rodlike liquid metal nanomachines have great potential for biomedical applications.

中文翻译:

可变形的可熔棒状游泳液态金属纳米机

可以转换和自我修复的T-1000液态金属终结者代表着数十年来的梦想,即机器人可以从根本上改变我们的日常生活。迄今为止,已经开发了一些大型液态金属机器。但是,没有关于纳米级液态金属机器及其生物医学应用的报道。我们在此描述一种基于生物相容性和可变形液态金属镓的可变形且可熔的棒状游泳液态金属纳米机。这些纳米机器是通过压力过滤模板技术制备的,其直径和长度可以通过调节纳米孔模板,过滤时间和压力来控制。所制备的液态镓纳米电动机显示出由液态镓核和固态氧化镓壳组成的核-壳纳米棒结构。暴露在超声场中 悬浮平面中产生的声辐射力可以推动它们自主移动。由于去除了酸性内体中的氧化镓层,液态金属纳米机器可以主动寻找癌细胞并在钻入细胞后从杆状体转变为液滴。这些经过改造的纳米机器可以在细胞内部融合在一起,并在近红外光的照射下光热杀死癌细胞。这种以声学方式推进的可变形形状的棒状液态金属纳米机器在生物医学应用中具有巨大的潜力。由于去除了酸性内体中的氧化镓层,液态金属纳米机器可以主动寻找癌细胞并在钻入细胞后从杆状体转变为液滴。这些经过改造的纳米机器可以在细胞内部融合在一起,并在近红外光的照射下光热杀死癌细胞。这种以声学方式推进的可变形形状的棒状液态金属纳米机器在生物医学应用中具有巨大的潜力。由于去除了酸性内体中的氧化镓层,液态金属纳米机器可以主动寻找癌细胞并在钻入细胞后从杆状体转变为液滴。这些经过改造的纳米机器可以在细胞内部融合在一起,并在近红外光的照射下光热杀死癌细胞。这种以声学方式推进的可变形形状的棒状液态金属纳米机器在生物医学应用中具有巨大的潜力。
更新日期:2018-09-19
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