A mild and transition-metal-free approach for the synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines via [2,3] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines with arynes is described. This protocol provides straightforward access to (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines in moderate to good yields with excellent diastereoselectivity. A broad range of functional groups, involving nitrile, esters, ketone and aryl halide, were well tolerated in this reaction.

中文翻译：

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芳烃诱导的[2,3] 1,2,3,4-四氢异喹啉的史蒂文斯重排，可合成简明的（E）-3-芳基-2,3,4,5-四氢-1 H -3-苯并zon嗪

用于合成的温和和过渡金属-自由的方法（ê）-3-芳基-2,3,4,5-四氢-1H-1 ħ -3- benzazonines通过[2,3]的1,2-史蒂文斯重排，描述了具有芳烃的3，4-四氢异喹啉。该协议提供了以中等到良好的产率和优异的非对映选择性直接获得（E）-3-芳基-2,3,4,5-四氢-1 H -3-苯并zon嗪的方法。在该反应中，对腈，酯，酮和卤代芳基等多种官能团的耐受性良好。