Subclinical inflammation is frequently noted in chronic diseases such as diabetes, cardiovascular disease (CVD) and obesity. Accumulating epidemiological evidence demonstrates that diets rich in vegetables and fruits, e.g., cherries, may significantly reduce the risk of chronic disease, in part, via antioxidant and anti-inflammatory activities. In this randomized, placebo-controlled crossover study, we recruited 10 at-risk participants (38.1 ± 12.5 years; 8 females, 2 males) with BMI >25.0 kg m⁻² (32.2 ± 4.6 kg m⁻²; 5 obese, 5 overweight) to consume 240 mL (8 ounces) daily of either 100% tart cherry juice (TCJ) or an alternate placebo beverage, for 4 weeks with a 2-week intervening washout period before switching to the alternate beverage for four weeks. Fasting blood samples were collected at the beginning and end of each arm for measurement of biomarkers of inflammation. The erythrocyte sedimentation rate (ESR), an indicator of chronic inflammation, was significantly (p < 0.05) lower with TCJ than with the placebo beverage, which increased ESR by 19%. Mean baseline hsCRP, an indicator of acute inflammation, was 7.0 ± 5.2 mg L⁻¹ and consumption of TCJ did not affect hsCRP levels. The chemokine MCP-1 and cytokine TNF-alpha were lower in participants after consuming TCJ compared to those consuming the placebo beverage. Plasma IL-6 and IL-l0 were not different between treatments. Collectively, the data suggest that authentic 100% TCJ may reduce biomarkers of inflammation often noted in chronic disease and may be a preferable dietary selection compared to artificially flavored beverages with added sugars.

中文翻译：

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正宗的酸樱桃汁减少了超重和肥胖受试者的炎症标志物：一项随机，交叉试验研究

在诸如糖尿病，心血管疾病（CVD）和肥胖症等慢性疾病中经常注意到亚临床炎症。越来越多的流行病学证据表明，富含蔬菜和水果（例如樱桃）的饮食可能会部分地通过抗氧化剂和抗炎活性来显着降低慢性疾病的风险。在这项随机，安慰剂对照的交叉研究中，我们招募了10名BMI> 25.0 kg m ^-2（32.2±4.6 kg m ^-2）的高风险参与者（38.1±12.5岁； 8名女性，2名男性）。; 5个肥胖，5个超重），每天要消耗240毫升（8盎司）100％酸樱桃汁（TCJ）或替代安慰剂饮料，持续4周，中间需要2周的冲洗期，然后再转换为4种替代饮料周。在每只手臂的开始和结束时采集空腹血样，以测量炎症的生物标志物。TCJ的红细胞沉降率（ESR）显着（p <0.05）比安慰剂饮料低（p <0.05），安慰剂饮料使ESR增加19％。基线hsCRP（急性炎症指标）的平均值为7.0±5.2 mg L ^-1TCJ的使用并没有影响hsCRP水平。与服用安慰剂饮料的受试者相比，服用TCJ的受试者的趋化因子MCP-1和细胞因子TNF-α较低。治疗之间血浆IL-6和IL-10没有差异。总体而言，数据表明，纯正的100％TCJ可以减少慢性病中经常注意到的炎症生物标志物，并且与添加糖的人工调味饮料相比，可能是更可取的饮食选择。