A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m⁻³ day⁻¹ in a mixer mill to 3395 kg m⁻³ day⁻¹ in a twin screw extruder.

中文翻译：

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将固态有机合成从混合机转化为连续双螺杆挤出机

本文讨论了从机械化学混合机向连续双螺杆挤出机的固态合成反应转化的研究。该研究强调了在模型氟化反应的背景下要进行的一些考虑和要测试的参数，这是首次尝试使用挤出法进行的有机氟化。经过优化后，首先使用研磨辅助固体以实现有效的合成挤出，将二氟化反应成功转移到挤出机中，从而使时空产率（STY）提高了100倍；在混合研磨机中为29 kg m ^-3天^-1，在双螺杆挤出机中为3395 kg m ^-3天^-1。