Cordyceps kyushuensis is the only species of cordyceps growing on the larvae of Clanis bilineata Walker, and has been demonstrated that there are lots of pharmacological components including cordycepin. Cordycepin shows lots of pharmacological action but it could be converted to 3′-deoxyinosine by adenosine deaminase in vivo, which weakens the efficiency of cordycepin. That pentostatin, which has been reported to inhibit adenosine deaminase, combining cordycepin could enhance the efficiency of cordycepin in vivo. During transcriptome and proteomics analysis of Cordyceps kyushuensis, a single gene cluster including four genes we named ck1-ck4 which can synthesis both cordycepin and pentostatin has been identified using BLAST. Meanwhile, KEGG, KOG, GO analysis and differentially expressed genes were analyzed in transcriptome and proteomics. This study first sequenced transcriptome and proteomics of C. kyushuensis, and demonstrated that there is a single gene cluster related to biosynthesis of cordycepin and pentostatin, which can be employed to improve the yield of cordycepin and find more functional proteins.

九州冬虫夏草是唯一生长在Clanis bilineata Walker幼虫上的冬虫夏草种类，并且已证明其具有许多药理成分，包括冬虫夏草。虫草素具有许多药理作用，但在体内可以被腺苷脱氨酶转化为3'-脱氧肌苷，从而减弱虫草素的功效。据报道，喷喷抑菌素可以抑制腺苷脱氨酶，与虫草素合用可以提高虫草素在体内的效率。九州虫草的转录组和蛋白质组学分析，使用BLAST已鉴定出一个单一基因簇，其中包括四个我们称为ck1-ck4的基因，它们可以合成冬虫夏草和喷司他丁。同时，在转录组和蛋白质组学中分析了KEGG，KOG，GO分析和差异表达基因。本研究第一测序转录和蛋白质组学C.九州，并表明存在与虫草素和喷司他丁的生物合成的单基因簇，其可被用来改善虫草素的产率和找到更多的功能蛋白质。