In this work, we have designed a novel green method for synthesis of a set pharmaceutically important spiro pyrazole and benzo[7, 8]chromene derivatives. These derivatives have been synthesized from various substituted isatins in turns with ethylacetoacetate, 2‐hydroxy‐1,4‐naphthaquionone/malonitrile and hydrazines or phenylhydrazine in presence of different catalysts in one‐pot four component method. We have optimized the synthetic conditions such as catalyst, solvent and time of reaction to get the maximum yield. Various lewis acids as catalyst and polar solvents as reaction medium were used in the multicomponent reactions (MCRs). Among the different catalysts and solvents tried NbCl₅ and ethanol have been identified as most effective catalyst and solvent respectively. The synthesized compounds are confirmed by FT‐IR, 1D and 2D NMR spectroscopic techniques.

中文翻译：

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NbCl5催化的吡咯并吡唑和苯并[7，8]色烯衍生物的一锅四组分合成

在这项工作中，我们设计了一种新颖的绿色方法，用于合成一组具有重要药学意义的螺吡唑和苯并[7，8]色烯衍生物。这些衍生物是由各种取代的靛红依次用乙酰乙酸乙酯，2-羟基-1,4-萘醌/丙二腈和肼或苯肼在不同的催化剂存在下通过一锅四组分方法合成的。我们优化了合成条件，例如催化剂，溶剂和反应时间，以获得最大的收率。在多组分反应（MCR）中使用了各种路易斯酸作为催化剂，极性溶剂作为反应介质。在不同的催化剂和溶剂中尝试使用NbCl ₅乙醇和乙醇分别被认为是最有效的催化剂和溶剂。通过FT-IR，1D和2D NMR光谱技术确认了合成的化合物。