A ligand-accelerated, branch-selective oxidative cyanation of alkenes has been developed in the presence of catalytic Cu₂O. Both styrenes and aliphatic alkenes with directing groups are well tolerated in this inexpensive protocol. The mild condition allows for a good tolerance of functional groups, enabling facile access to a diverse array of simple and complex branched vinyl nitriles. The wide synthetic utility of this methodology has been further demonstrated via the efficient scaleup in both batch and continuous flow processes.

中文翻译：

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烯烃的配体加速、分支选择性氧化氰化

_{在催化 Cu 2} O存在的情况下，已经开发了烯烃的配体加速、支链选择性氧化氰化。在这种廉价方案中，苯乙烯和具有导向基团的脂肪族烯烃都具有良好的耐受性。温和的条件允许对官能团具有良好的耐受性，从而能够轻松获得各种简单和复杂的支化乙烯基腈。通过在批处理和连续流过程中的有效放大，进一步证明了该方法的广泛合成效用。