We designed an enzyme-activatable probe for real time in situ tracking of MT1-MMP activity. The MT1-MMP responses of endothelial cells were investigated under the regulation of shear stress and biochemical factor on a microfluidic chip. This strategy can be beneficial to evaluate membrane protein responses to external stimuli and to engineer cells for basic and clinical research.

中文翻译：

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在微流控芯片上实时成像细胞膜定位的MT1-MMP活性†

我们设计了一种酶可活化探针，用于实时原位跟踪MT1-MMP活性。在微流控芯片上，在剪切应力和生化因子的调节下，研究了内皮细胞的MT1-MMP反应。该策略对于评估膜蛋白对外部刺激的反应以及对细胞进行工程设计以进行基础和临床研究可能是有益的。