Biodegradable polymers are of current interest and chemical functionality in such materials is often demanded in advanced biomedical applications. Functional groups often are not tolerated in the polymerization process of ring-opening polymerization (ROP) and therefore protective groups need to be applied. Advantageously, several orthogonally reactive functions are available, which do not demand protection during ROP. We give an insight into available, orthogonally reactive cyclic monomers and the corresponding functional synthetic and biodegradable polymers, obtained from ROP. Functionalities in the monomer are reviewed, which are tolerated by ROP without further protection and allow further post-modification of the corresponding chemically functional polymers after polymerization. Synthetic concepts to these monomers are summarized in detail, preferably using precursor molecules. Post-modification strategies for the reported functionalities are presented and selected applications highlighted.

中文翻译：

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通过无保护基团的单体的开环聚合反应来制备 可生物降解的功能性聚合物

可生物降解的聚合物是当前的关注点，并且在先进的生物医学应用中经常需要这种材料的化学功能。在开环聚合（ROP）的聚合过程中通常不容许官能团，因此需要应用保护基。有利地，可以使用几种正交反应功能，这些功能在ROP期间不需要保护。我们深入了解了从ROP获得的可用的，具有正交反应性的环状单体以及相应的功能性合成和可生物降解的聚合物。对单体中的官能度进行了综述，ROP可以耐受这些官能度而无需进一步保护，并且可以在聚合后对相应的化学官能聚合物进行进一步的后改性。对这些单体的合成概念进行了详细总结，优选使用前体分子。提出了报告功能的修改后策略，并突出显示了选定的应用程序。