Abstract The application of three-dimensional (3D) printed scaffolds for tissue engineering have gained significant attention in recent years. The biological activity of scaffolds used in tissue engineering applications depends on fabricating high-resolution patterns with fiber orientation and scale. In this study, Bacterial Cellulose (BC) and Polycaprolactone (PCL) composite scaffolds with the line spacing of 100 µm are produced using Electrohydrodynamic (EHD)-3D-bioprinting technique. The composite scaffolds exhibit enhanced biocompatibility with facilitated cell attachment and proliferation in vitro. The results of this work have demonstrated that EHD-3D-bioprinting method shows great potential for the preparation of BC/PCL composite scaffold and patterns for tissue engineering with enhanced bioactivity.

中文翻译：

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用于组织工程的电流体动力学 (EHD)-3D 生物打印细菌纤维素\聚己内酯支架的细胞研究

摘要 近年来，三维（3D）打印支架在组织工程中的应用受到了广泛关注。用于组织工程应用的支架的生物活性取决于制造具有纤维取向和比例的高分辨率图案。在这项研究中，使用电流体动力学 (EHD)-3D 生物打印技术生产线间距为 100 µm 的细菌纤维素 (BC) 和聚己内酯 (PCL) 复合支架。复合支架表现出增强的生物相容性，促进体外细胞附着和增殖。这项工作的结果表明，EHD-3D 生物打印方法在制备具有增强生物活性的 BC/PCL 复合支架和组织工程图案方面具有巨大潜力。