RNA molecules can perform a myriad of functions, from the regulation of gene expression to providing the genetic blueprint for protein synthesis. Characterizing RNA expression dynamics, in a cell-specific manner, still remains a great challenge in biology. Herein we present a new set of protected alkynyl nucleosides for cell-specific metabolic labeling of RNA. We anticipate these analogs will find wide spread utility toward the goal of understanding RNA expression in complex cellular and tissue environments, even within living animals.

中文翻译：

---

用于 RNA 细胞特异性代谢标记的受保护的嘧啶核苷

RNA 分子可以执行多种功能，从基因表达的调节到为蛋白质合成提供遗传蓝图。以细胞特异性方式表征 RNA 表达动态仍然是生物学中的巨大挑战。在此，我们提出了一组新的受保护的炔基核苷，用于细胞特异性 RNA 代谢标记。我们预计这些类似物将具有广泛的用途，以实现理解复杂细胞和组织环境中甚至活体动物中 RNA 表达的目标。