Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking†,Chemical Communications

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Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1039/c8cc05614e
Cheng Lv _{1,

2,

3} , Yi Lin _{1,

2,

3} , En-Ze Sun _{1,

2,

3} , Bo Tang _{1,

2,

3} , Jian Ao _{1,

2,

3} , Jia-Jia Wang _{1,

2,

3} , Zhi-Ling Zhang _{1,

2,

3} , Zhenhua Zheng _{3,

4,

5} , Hanzhong Wang _{3,

4,

5} , Dai-Wen Pang _{1,

2,

3}

Affiliation

With the aid of the single-virus tracking technique and the quantum dot-labeling strategy, the internalization of the pseudorabies virus (PrV) has been visualized in real time. The results demonstrate that macropinocytosis can be considered as a major pathway for PrV entering HeLa cells, which facilitates the development of therapeutics for virus-triggered diseases.

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