Four stochastic microsensors were proposed for the molecular recognition of insulin, Proinsulin C Peptide (55–89), leptin, adiponectin and CRP in serum samples. The microsensors were design by physical immobilization of protoporphyrin PIX, phthalocyanine‐BODIPY dye (BODIPY=boron dipyrromethene), inulins such as TEX or ionic liquids such as L‐alanine‐tert‐butyl‐ester‐L‐lactate (L‐AlaC₄‐Lac) in matrices such as diamond paste and Au‐TiO₂/rGR paste. The proposed microsensors were reliable for the molecular recognition and quantification of the biomarkers. For the determination of Proinsulin C Peptide (55–89), insulin, leptin, adiponectin and CRP the immunoassay techniques are routinely used in clinical practice, requiring five types of detection kits, therefore one of the main advantage in using this method consists in determining in one run all the analytes.

中文翻译：

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糖尿病相关生物标志物的模式识别

建议使用四个随机微传感器对血清样品中的胰岛素，胰岛素原C肽（55-89），瘦素，脂联素和CRP进行分子识别。所述微传感器是通过原卟啉PIX，酞菁-BODIPY染料（BODIPY =硼二吡咯亚甲基）的物理固定化设计，菊粉如TEX或离子液体，例如L-丙氨酸叔丁基酯基-L-乳酸（L-ALAC ₄ - Lac）在钻石浆和Au-TiO ₂等基质中/ rGR粘贴。所提出的微传感器对于生物标记的分子识别和定量是可靠的。为了测定胰岛素原C肽（55-89），胰岛素，瘦素，脂联素和CRP，免疫测定技术通常用于临床实践，需要五种类型的检测试剂盒，因此使用此方法的主要优势之一在于确定一次运行所有分析物。