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Asymmetric Copper-Catalyzed C(sp)–H Bond Insertion of Carbenoids Derived from N-Tosylhydrazones
Synlett ( IF 2 ) Pub Date : 2018-09-14 , DOI: 10.1055/s-0037-1611003
Yasuhiro Uozumi 1 , Takao Osako , Makoto Nagaosa , Go Hamasaka
Affiliation  

A chiral copper(I)–phosphoramidite complex efficiently catalyzed the asymmetric insertion of the carbenoids derived from N-tosyl hydrazones into alkyne C–H bonds to give the corresponding chiral alkynylated products in up to 77% yield and with up to 74% ee.

中文翻译:

N-甲苯磺酰腙衍生的类卡宾的不对称铜催化 C(sp)-H 键插入

手性铜(I)-亚磷酰胺络合物有效催化源自 N-甲苯磺酰腙的类卡宾不对称插入炔烃 C-H 键,以高达 77% 的产率和高达 74% 的 ee 得到相应的手性炔基化产物。
更新日期:2018-09-14
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