In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, ¹H, ³¹P NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA.

中文翻译：

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包括亚芴基桥接的环磷腈在内的新型环磷腈衍生物的生物活性

在这项研究中，合成了新的环磷腈化合物，并对其生物学活性进行了研究。通过元素分析，质谱，¹ H，³¹ P NMR技术验证了化合物的结构研究。随后，利用DNA相互作用分析和利用pUC18质粒的切割方法，筛选了合成化合物对DNA的作用。结果表明，化合物14，40和45引起的晶型III（线性化的DNA）的质粒DNA，表明这些化合物与质粒DNA的相互作用。