当前位置: X-MOL 学术Polym. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Peptide–dendron hybrids that adopt sequence-encoded β-sheet conformations†
Polymer Chemistry ( IF 4.6 ) Pub Date : 2018-09-13 00:00:00 , DOI: 10.1039/c8py00882e
Deborah A Barkley 1 , Sang Uk Han 1 , Tadanori Koga 1, 2 , Jonathan G Rudick 1
Affiliation  

Rational design rules for programming hierarchical organization and function through mutations of monomers in sequence-defined polymers can accelerate the development of novel polymeric and supramolecular materials. Our strategy for designing peptide–dendron hybrids that adopt predictable secondary and quaternary structures in bulk is based on patterning the sites at which dendrons are conjugated to short peptides. To validate this approach, we have designed and characterized a series of β-sheet-forming peptide–dendron hybrids. Spectroscopic studies of the hybrids in films reveal that the peptide portion of the hybrids adopts the intended secondary structure.

中文翻译:

采用序列编码的 β-折叠构象的肽-树突杂合体†

通过序列定义的聚合物中单体的突变来编程分层组织和功能的合理设计规则可以加速新型聚合物和超分子材料的开发。我们设计批量采用可预测的二级和四级结构的肽-树突杂化物的策略是基于对树突与短肽缀合的位点进行图案化。为了验证这种方法,我们设计并表征了一系列形成β-折叠的肽-树突杂合体。对薄膜中杂交体的光谱研究表明,杂交体的肽部分采用了预期的二级结构。
更新日期:2018-09-13
down
wechat
bug