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A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-09-11 00:00:00 , DOI: 10.1039/c8cc06556j
André Shamsabadi 1, 2, 3, 4 , Vijay Chudasama 1, 2, 3, 4
Affiliation  

Herein we report the transformation of readily synthesised acyl hydrazides into 2-hydrazobenzophenones via a novel molecular rearrangement pathway using aryne chemistry. The developed reaction protocol is performed under relatively mild conditions and is tolerant of a wide variety of functional groups, and the 2-hydrazobenzophenone products provide access to both 1H- and 2H-indazoles from a single intermediate.

中文翻译:

通过利用新型的基于芳烃的分子重排从容易获得的酰肼 制备1 H-和2 H-吲唑的简便途径

在本文中,我们报告了使用芳烃化学反应通过新型分子重排途径将易于合成的酰肼转化为2-肼基二苯甲酮。发达的反应方案在相对温和的条件下进行,并能耐受多种官能团,并且2-肼基二苯甲酮产品可从单一中间体同时获得1 H-和2 H-吲唑。
更新日期:2018-09-11
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