Three new gold(I)–coumarin‐based trackable therapeutic complexes and two non‐trackable analogues have been synthesised and fully characterised. They all display anti‐proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti‐inflammatory effects; one displayed pro‐inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two‐photon microscopy.

中文翻译：

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金（I）-香豆素-咖啡因基复合物是新型潜在的抗炎和抗癌药物

合成了三种新的基于金（I）-香豆素的可追踪治疗复合物和两种不可追踪的类似物。它们都对多种类型的癌细胞系表现出抗增殖特性，包括结肠癌，乳腺癌和前列腺癌。两种复合物显示出显着的抗炎作用；一种表现出促炎行为; 这突出了荧光团的位置对咖啡因支架的影响。此外，可以通过双光子显微镜在体外观察到三种香豆素衍生物。