Naringin, a flavanone glycoside, and naringenin, the aglycone of naringin, are commonly found in the pericarp of citrus fruits and have also been considered as potential bioactive flavanones. In the present study, treatment with naringenin showed an inhibitory effect on SIV formation in zebrafish embryos, which demonstrates its potential anti-angiogenic activity. In a chemically-induced blood vessel loss model in zebrafish, we found that naringin exhibited remarkably pro-angiogenesis activity on the restoration of blood vessel loss, and significantly reversed VRI-induced down-regulation of flt1 mRNA expression. In an in vitro study of cultured human umbilical vein endothelial cells (HUVEC), our results showed that naringin specifically promoted HUVEC migration but not proliferation. Taken together, these results suggest that naringin and naringenin have differential angiogenesis activities where naringin, as a novel angiogenic agent, has the potential to be developed as a therapeutic agent for diseases associated with insufficient angiogenesis, such as ischemia heart disease.

柚皮苷是一种黄烷酮苷，柚皮苷是一种柚皮苷，通常在柑橘类水果的果皮中发现，也被认为是潜在的生物活性黄烷酮。在本研究中，柚皮苷处理对斑马鱼胚胎中的SIV形成具有抑制作用，表明其潜在的抗血管生成活性。在斑马鱼的化学诱导的血管丢失模型中，我们发现柚皮苷对血管丢失的恢复具有显着的促血管生成活性，并显着逆转了VRI诱导的flt1 mRNA表达的下调。在体外在对培养的人脐静脉内皮细胞（HUVEC）进行的研究中，我们的结果表明，柚皮苷能专门促进HUVEC迁移，但不能促进增殖。综上所述，这些结果表明柚皮苷和柚皮苷具有不同的血管生成活性，其中柚皮苷作为一种新型血管生成剂，有可能被开发为与血管生成不足有关的疾病（如缺血性心脏病）的治疗剂。