Procyanidins are a group of flavonoids that can be found in many plants. The objective of the current study was to investigate the anti-obesity effect of procyanidin on high fat diet induced obese C57BL/6J mice. The mice were administrated with 100 mg/kg procyanidin for 12 weeks. The results showed that consumption of procyanidin significantly ameliorated high fat diet induced obesity and its associated risk factors, including reduction of body weight gain, lipid profile improvement and increase of energy expenditure. Moreover, microbial 16S rRNA gene sequencing of the feces demonstrated that procyanidin administration markedly increased intestinal microbiota β diversity and Bacteroidetes quantities but decreased the Firmicutes/Bacteroidetes ratio. We conclude that supplementation with procyanidin prevents obesity and modifies the gut microbiota composition.

原花青素是可在许多植物中发现的一组类黄酮。本研究的目的是研究原花青素对高脂饮食诱导的肥胖C57BL / 6J小鼠的抗肥胖作用。给小鼠施用100mg / kg原花青素，持续12周。结果表明，食用原花青素可显着改善高脂饮食引起的肥胖及其相关的危险因素，包括减少体重增加，改善脂质状况和增加能量消耗。此外，粪便的微生物16S rRNA基因测序证明原花青素的给药显着增加了肠道菌群β多样性和拟杆菌数量，但降低了Firmicutes / Bacteroidetes比率。我们得出结论，补充原花青素可预防肥胖症并改变肠道菌群组成。