β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical β-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug discovery strategies aimed toward new β-lactam antibiotics with this profile.

中文翻译：

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β-内酰胺类抗生素的药代动力学：过去的线索有助于在未来发现长效口服药物。

β-内酰胺类可能代表了迄今为止发现的最重要的一类抗生素。然而，尽管进行了多年的积极研究，目前已获批准的此类药物中没有一种将口服活性与长作用时间相结合。最近的发展表明，具有这种特性的新型 β-内酰胺抗生素可用于治疗结核病。因此，对历史 β-内酰胺药代动力学数据进行了汇编和分析，以确定可能的方向和药物发现策略，旨在针对具有此特征的新型 β-内酰胺抗生素。