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Effect of ionic strength on bioaccumulation and toxicity of silver nanoparticles in Caenorhabditis elegans
Ecotoxicology and Environmental Safety ( IF 6.8 ) Pub Date : 2018-09-08 , DOI: 10.1016/j.ecoenv.2018.09.008
Yaning Yang , Guangmin Xu , Shengmin Xu , Shaopeng Chen , An Xu , Lijun Wu

The behavior of silver nanoparticles (AgNPs) is influenced by environmental factors which altered their bioaccumulation and toxicity. In this study, we comprehensively investigated the influence of ionic strength on the ecotoxicity of AgNPs to Caenorhabditis elegans (C. elegans) through the transfer from Escherichia coli (E. coli). Three different exposure media (deionized water, EPA water and KM) were used to pretreat AgNPs. E. coli was then exposed to these transformed AgNPs and fed to C. elegans. Our results indicated that ionic strength significantly enhanced the reproductive toxicity (germ cell corpses, brood size and lifespan) and neurotoxicity (head trash and body bend) of AgNPs in C. elegans. Moreover, ICP-MS analysis showed that higher ionic strength increased bioaccumulation of AgNPs in E. coli and the resulting Ag body burden of E. coli affected the transfer of AgNPs to C. elegans, which might be responsible for the increased toxicity to nematodes. Furthermore, we also found that the reactive oxygen species (ROS) level in C. elegans was significantly increased after exposed to E. coli contaminated with ionic strength-treated AgNPs, which might play another important role for the enhanced toxicity of AgNPs. Overall, this study showed that the bioavailability and potential ecotoxicity of AgNPs are associated with the environmental factors.



中文翻译:

离子强度对秀丽隐杆线虫中银纳米颗粒生物富集和毒性的影响

银纳米颗粒(AgNPs)的行为受到环境因素的影响,这些环境因素改变了它们的生物蓄积性和毒性。在这项研究中,我们全面研究了离子强度通过从大肠杆菌(E. coli)转移对AgNPs对秀丽隐杆线虫C. elegans)的生态毒性的影响。三种不同的接触介质(去离子水,EPA水和KM)用于预处理AgNP。然后将大肠杆菌暴露于这些转化的AgNPs,并喂食秀丽隐杆线虫。我们的结果表明,离子强度显着增强了AgNPs在小鼠体内的生殖毒性(生殖细胞尸体,育雏尺寸和寿命)和神经毒性(头部垃圾和身体弯曲)。秀丽隐杆线虫。此外,ICP-MS分析表明,较高离子强度的增加的AgNPs的生物蓄积性大肠杆菌和所得到的Ag身体负担大肠杆菌影响的AgNPs转移到线虫,这可能是负责增加的毒性线虫。此外,我们还发现,暴露于被离子强度处理过的AgNPs污染的大肠杆菌后,秀丽隐杆线虫中的活性氧(ROS)水平显着增加,这可能对提高AgNPs的毒性起着重要的作用。总体而言,这项研究表明,AgNPs的生物利用度和潜在的生态毒性与环境因素有关。

更新日期:2018-09-08
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