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Study of active self-assembly using biomolecular motors
Polymer Journal ( IF 2.8 ) Pub Date : 2018-09-07 , DOI: 10.1038/s41428-018-0109-8
Arif Md. Rashedul Kabir , Akira Kakugo

AbstractSelf-propelled biomolecular motor systems, such as microtubule-kinesin or microtubule-dynein, are intricate natural machines with the ability to convert chemical energy into mechanical work with high efficiency. In recent years, the biomolecular motor systems have emerged as promising candidates for studying active self-assembly based on the in vitro gliding assay of the motor systems. Several strategies have been developed to demonstrate the active self-assembly of biomolecular motors, which provided a wealth of organized and complex structures. Here we review the latest progress in the active self-assembly of microtubule-kinesin and microtubule-dynein with an emphasis on the emergence of various structures and necessary design parameters for controlling their polymorphism.Recent advances in the study of active self-assembly utilizing biomolecular motors are reviewed. Various methodologies developed for demonstrating active self-assembly of biomolecular motors are discussed in detail with an emphasis on the morphological variations of the self-assembled structures.

中文翻译:

使用生物分子马达进行主动自组装的研究

摘要 自驱动生物分子运动系统,如微管驱动蛋白或微管驱动蛋白,是复杂的自然机器,能够将化学能高效地转化为机械功。近年来,生物分子运动系统已成为基于运动系统的体外滑动试验研究主动自组装的有希望的候选者。已经开发了几种策略来证明生物分子马达的主动自组装,这提供了丰富的有组织和复杂的结构。在这里,我们回顾了微管-驱动蛋白和微管-动力蛋白主动自组装的最新进展,重点是各种结构的出现和控制其多态性的必要设计参数。综述了利用生物分子马达进行主动自组装研究的最新进展。详细讨论了为证明生物分子马达的主动自组装而开发的各种方法,重点是自组装结构的形态变化。
更新日期:2018-09-07
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