Spinosyn A is an important polycyclic natural product with impressive insecticidal activity and has been used worldwide in agriculture as the major component of Spinosad. Herein, four chemical total syntheses of spinosyn A are summarized. Its biosynthesis and a chemoenzymatic total synthesis are discussed as well. 1 Biosynthesis 2 The Evans Synthesis 3 The Paquette Synthesis 4 The Roush Synthesis 5 The Liu Synthesis 6 The Dai Synthesis 7 Conclusions

中文翻译：

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多杀菌素 A 的全合成

多杀菌素 A 是一种重要的多环天然产物，具有令人印象深刻的杀虫活性，作为多杀菌素的主要成分已在全球范围内用于农业。在此，总结了多杀菌素A的四种化学全合成。还讨论了它的生物合成和化学酶促全合成。1 生物合成 2 Evans 合成 3 Paquette 合成 4 Roush 合成 5 Liu 合成 6 Dai 合成 7 结论