Poly(ε-caprolactone)/poly(lactic acid) (PCL/PLA) blends are very promising materials with biodegradable characteristics and tailorable performance for many applications. In this study, PCL and PLA were compounded at various ratios using a co-rotating twin-screw extruder. The morphology showed that they were immiscible but were dispersed well in each other. Very interesting and peculiar open-cell structures were obtained through a batch-foaming process. Interconnected holes with flexible PCL fibrils were created by high tensile stress during cell expansion, which contributed to the rapid diffusion of CO₂. No cells collapsed at high foam expansion under all foaming conditions. Moreover, a small-diameter tubular PCL/PLA foamed scaffold had a tensile toe region of approximately 40%, which indicated a potential application for vascular tissue engineering. The human umbilical vein endothelial cells cultured on the surfaces of PCL/PLA blend foams showed high viability and migration.

中文翻译：

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用于组织工程支架的新型聚（ε-己内酯）/聚（乳酸）共混物开孔泡沫的制备

聚（ε-己内酯）/聚乳酸（PCL / PLA）共混物是非常有前途的材料，具有可生物降解的特性和可定制的性能，可用于许多应用。在这项研究中，使用同向旋转双螺杆挤出机将PCL和PLA配制成各种比例。形态表明它们是不溶混的，但彼此分散得很好。通过分批发泡过程获得了非常有趣且独特的开孔结构。在细胞膨胀过程中，高拉伸应力产生了带有柔性PCL原纤维的互连孔，这有助于CO ₂的快速扩散。在所有发泡条件下，没有气泡在高泡沫膨胀下塌陷。此外，小直径管状PCL / PLA泡沫支架的脚趾拉伸区域约为40％，这表明其在血管组织工程中的潜在应用。在PCL / PLA共混泡沫表面上培养的人脐静脉内皮细胞显示出较高的生存能力和迁移能力。