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A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels.
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2018-10-18 , DOI: 10.1002/anie.201808908
Markus Lunzer 1, 2, 3 , Liyang Shi 4 , Orestis G Andriotis 3, 5 , Peter Gruber 1, 3 , Marica Markovic 1, 3 , Philipp J Thurner 3, 5 , Dmitri Ossipov 4, 6 , Robert Liska 2, 3 , Aleksandr Ovsianikov 1, 3
Affiliation  

Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo-induced degradation of such hydrogel systems is commonly based on the integration of photolabile o-nitrobenzyl derivatives to the hydrogel backbone, because such linkers can be cleaved by means of one- and two-photon absorption. Herein we describe a cytocompatible click-based hydrogel containing o-nitrobenzyl ester linkages between a hyaluronic acid backbone, which is photodegradable in the presence of cells. It is demonstrated for the first time that by using a cyclic benzylidene ketone-based small molecule as photosensitizer the efficiency of the two-photon degradation process can be improved significantly. Biocompatibility of both the improved two-photon micropatterning process as well as the hydrogel itself is confirmed by cell culture studies.

中文翻译:

光可降解水凝胶敏化双光子图案化的模块化方法。

可光降解水凝胶已成为细胞功能、组织工程和细胞递送研究的有用平台,因为它们的物理和化学性质可以通过光的使用来动态控制。此类水凝胶系统的光诱导降解通常基于对光不稳定的邻硝基苯甲基衍生物与水凝胶主链的整合,因为此类连接体可以通过一光子和二光子吸收的方式裂解。在此,我们描述了一种基于细胞相容性点击的水凝胶,其在透明质酸主链之间含有邻硝基苄酯键,其在细胞存在下可光降解。首次证明,通过使用环亚苄基酮基小分子作为光敏剂,可以显着提高双光子降解过程的效率。细胞培养研究证实了改进的双光子微图案化工艺以及水凝胶本身的生物相容性。
更新日期:2018-10-18
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