Maternal Red Blood Cell Folate and Infant Vitamin B12 Status Influence Methylation of Genes Associated with Childhood Acute Lymphoblastic Leukemia,Molecular Nutrition & Food Research

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Maternal Red Blood Cell Folate and Infant Vitamin B12 Status Influence Methylation of Genes Associated with Childhood Acute Lymphoblastic Leukemia
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-10-11 , DOI: 10.1002/mnfr.201800411
Catherine Potter ₁ , Anthony Vincent Moorman ₂ , Caroline Laura Relton ₃ , Dianne Ford ₄ , John Cummings Mathers ₅ , Gordon Strathdee ₂ , Jill Ann McKay _{4,

6}

Affiliation

Inadequate maternal folate intake is associated with increased childhood acute lymphoblastic leukemia (ALL) risk. Folate provides methyl groups for DNA methylation, which is dramatically disrupted in ALL. Whether or not maternal folate (and related B‐vitamin) intake during pregnancy may affect ALL risk via influencing DNA methylation is investigated.

中文翻译：

母体红细胞叶酸和婴儿维生素 B12 状态对儿童急性淋巴细胞白血病相关基因甲基化的影响

母亲叶酸摄入不足与儿童急性淋巴细胞白血病 (ALL) 风险增加有关。叶酸为 DNA 甲基化提供甲基，这在 ALL 中被显着破坏。研究了怀孕期间母亲叶酸（和相关的 B 族维生素）摄入量是否可能通过影响 DNA 甲基化来影响 ALL 风险。

更新日期：2018-10-11

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