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Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction
Synlett ( IF 2 ) Pub Date : 2018-09-06 , DOI: 10.1055/s-0037-1610234
Chuan Xu 1 , Zhong-Zhu Chen 2 , Zhi-Gang Xu 2 , Yong Ding 2 , Jiang-Ping Meng 2 , Dian-Yong Tang 2 , Yong Li 2 , Jie Lei 2
Affiliation  

A small series of hydantoins was efficiently synthesized via a two-step Ugi/cyclization reaction sequence using alkyne group as a leaving group under basic conditions. This microwave-assisted one-pot cyclization strategy could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like hydantoins.

中文翻译:

通过后 Ugi 级联反应轻松构建乙内酰脲支架

在碱性条件下,使用炔基作为离去基团,通过两步 Ugi/环化反应序列有效合成了一小部分乙内酰脲。这种微波辅助的一锅环化策略可适用于其他多组分反应(MCR),用于合成生物活性和类药物乙内酰脲。
更新日期:2018-09-06
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