Near-infrared (NIR) light possesses great advantages for light-responsive controlled drug release, such as deep tissue penetration and a less detrimental effect on healthy tissues. In this paper, we report a facile and efficient preparation of a NIR-triggered micelle system for a drug vehicle. The system consists of NIR-sensitive indocyanine green (ICG) and anticancer drug, doxorubicin (DOX) which are simultaneously encapsulated in core-cross-linked (CCL) micelles formed by the Diels–Alder click reaction between poly(ethylene oxide)-b-poly(furfuryl methacrylate) (PEO-b-PFMA) and a novel diselenide-containing bismaleimide cross-linker. Under NIR (808 nm) irradiation, ICG generates reactive oxygen species which can cleave diselenide bonds in the core of CCL micelles. This response to NIR irradiation allows the rapid release of DOX from the de-cross-linked micelles, leading to significantly enhanced apoptosis in HepG2 cells as evidenced by a cytotoxicity test and confocal laser scanning microscopy.

中文翻译：

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通过Diels–Alder点击反应制备的近红外光响应，含二硒化物的核心交联胶束，用于光控药物释放应用

近红外（NIR）光在光响应性受控药物释放方面具有巨大优势，例如深层组织渗透和对健康组织的有害影响较小。在本文中，我们报告了一种用于毒品载具的近红外触发胶束系统的简便有效的制备方法。该系统由对NIR敏感的吲哚菁绿（ICG）和抗癌药阿霉素（DOX）组成，它们同时封装在聚环氧乙烷-b之间的Diels–Alder点击反应形成的核心交联（CCL）胶束中。-聚（甲基丙烯酸糠酯）（PEO- b-PFMA）和新型的含二硒化物的双马来酰亚胺交联剂。在近红外（808 nm）辐射下，ICG产生活性氧，可以裂解CCL胶束核心中的二硒键。对NIR辐照的这种反应使DOX从解交联的胶束中快速释放出来，从而导致HepG2细胞的凋亡显着增强，这通过细胞毒性试验和共聚焦激光扫描显微镜得以证明。