Halloysite Nanotubes (HNTs) are clay minerals that possess unique chemical composition and a tubular structure due to which, they have recently emerged as a potential nanomaterial for umpteen applications. Over the years, the myriad applications of HNT have been realized through the surface modification of HNT, which involves the modification of nanotube's inner lumen and the outer surface with different functional compounds. The presence of aluminum and silica groups on the inner and outer surface of HNT enhance the interfacial relationship of the nanotube with different functional agents. Compounds such as alkalis, organosilanes, polymers, compounds of biological origin, surfactants and nanomaterials have been used for the modification of the inner lumen and the outer surface of HNT. The strategies change the constitution of HNT's surface either through micro-disintegration of the surface or by introducing additional functional groups on the surface, which further enhances their potential to be used as a flexible interface for different applications. In this review, the different surface modification strategies of the outer surface and the inner lumen that have been employed over the years have been discussed. The biological, environmental and catalytic applications of these surface modified HNTs with such versatile interface in the past two years have been elaborately discussed as well.

埃洛石纳米管（HNT）是具有独特化学成分和管状结构的粘土矿物，因此，它们最近已成为众多应用中潜在的纳米材料。多年来，HNT的各种应用已经通过HNT的表面改性得以实现，这涉及使用不同的功能化合物对纳米管的内腔和外表面进行改性。HNT的内表面和外表面上铝和硅烷基团的存在增强了纳米管与不同功能剂的界面关系。诸如碱，有机硅烷，聚合物，生物来源的化合物，表面活性剂和纳米材料之类的化合物已用于修饰HNT的内腔和外表面。这些策略改变了HNT'的构成 通过表面的微崩解或通过在表面上引入其他官能团，可以进一步提高其表面用作不同应用的柔性界面的潜力。在这篇综述中，讨论了多年来使用的外表面和内腔的不同表面改性策略。在过去的两年中，已经对具有这种通用界面的这些表面改性的HNT的生物学，环境和催化应用进行了详尽的讨论。讨论了多年来采用的外表面和内腔的不同表面改性策略。在过去的两年中，已经对具有这种通用界面的这些表面改性的HNT的生物学，环境和催化应用进行了详尽的讨论。讨论了多年来采用的外表面和内腔的不同表面改性策略。在过去的两年中，已经对具有这种通用界面的这些表面改性的HNT的生物学，环境和催化应用进行了详尽的讨论。