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fHyaluronic acid / Na-alginate films. As topical bioactive wound dressings
European Polymer Journal ( IF 6 ) Pub Date : 2018-12-01 , DOI: 10.1016/j.eurpolymj.2018.09.003
A. Abou-Okeil , H.M. Fahmy , M.K. El-Bisi , O.A. Ahmed-Farid

Abstract The current work was focused on formulation of new topical bioactive hyaluronic acid (HA)/Na-alginate (SA) films crosslinked with Ca2+, Zn2+, or Cu2+ metal cations. The antibacterial as well as some physico-mechanical properties of such crosslinked films such as gel fraction, swelling, tensile strength, stiffness, SEM, and water vapor permeability were discussed. Moreover, to enhance the antibacterial properties of the HA/SA/Ca2+ film, sulfadiazine (SD) alone or in combination with silver nanoparticles (AgNPs) as bioactive agents were incorporated in the formulation of that film. The in vitro releasing of sulfadiazine from such loaded film at different pH values was studied. The results obtained confirmed that among the above formulated films, the HA/SA/Ca2+/SD/Ag-NPs bio-film has the highest antibacterial activity. In addition, the above prepared films were screened as topical bioactive wound dressings for albino rats. The results indicated that both HA/SA/Ca2+/SD and HA/SA/Ca2+/SD/AgNPs films are effective dressings for restoring the homeostasis skin tissue of such rats to the normal control after 14 days, but the latter film was the best.

中文翻译:

f 透明质酸/海藻酸钠薄膜。作为局部生物活性伤口敷料

摘要 当前的工作集中在与 Ca2+、Zn2+ 或 Cu2+ 金属阳离子交联的新型局部生物活性透明质酸 (HA)/海藻酸钠 (SA) 薄膜的配方。讨论了这种交联薄膜的抗菌性以及一些物理机械性能,如凝胶分数、溶胀、拉伸强度、刚度、SEM 和水蒸气渗透率。此外,为了增强 HA/SA/Ca2+ 薄膜的抗菌性能,将磺胺嘧啶 (SD) 单独或与作为生物活性剂的银纳米颗粒 (AgNP) 结合用于该薄膜的配方中。研究了磺胺嘧啶在不同 pH 值下从这种负载膜中的体外释放。获得的结果证实,在上述配制的膜中,HA/SA/Ca2+/SD/Ag-NPs生物膜具有最高的抗菌活性。此外,上述制备的薄膜被筛选为用于白化大鼠的局部生物活性伤口敷料。结果表明,HA/SA/Ca2+/SD和HA/SA/Ca2+/SD/AgNPs薄膜均是使该类大鼠皮肤组织在14天后恢复到正常对照的有效敷料,但后一种薄膜效果最好。 .
更新日期:2018-12-01
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