Background and Aims

Rapid onsite evaluation of touch imprint cytology (ROSE-TIC) is a simple and rapid method used for the diagnosis of benign and malignant lesions. We evaluated the diagnostic accuracy of ROSE-TIC for advanced intestinal luminal and indeterminate pancreatobiliary lesions during endoscopy.

Methods

This is a retrospective descriptive study of patients who underwent endoscopy or ERCP between January 1, 2014 and December 31, 2016. It included patients who were referred for the treatment of intestinal luminal lesions or evaluation of indeterminate pancreatobiliary lesions. The slides were prepared by gently touching the specimen onto a glass slide and were examined under the microscope. The main outcome measure was to determine the diagnostic accuracy of ROSE-TIC by comparing the onsite cytology findings with the corresponding off-site histologic diagnosis.

Results

All 222 patients (106 pancreatobiliary and 116 GI lesions) had a prior benign diagnosis of intestinal luminal lesions or indeterminate diagnosis of pancreatobiliary lesions. The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of ROSE-TIC were 97%, 85%, 83%, 97.2%, and 90%, respectively. The accuracy varied with the site of the biopsy sample. The accuracy was lowest for upper GI tract, where it was 85.2% but was 95% for lower GI tract lesions.

Conclusions

By establishing a rapid onsite diagnosis, ROSE-TIC expedites decision-making on patient management. Prospective studies are needed to confirm these preliminary findings.

中文翻译：

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从内窥镜和胆管镜钳活检样本中快速评估触摸烙印细胞学的实用工具（带视频）

背景和目标

快速的触摸印迹细胞学现场评估（ROSE-TIC）是一种用于诊断良性和恶性病变的简单而快速的方法。我们评估了ROSE-TIC在内窥镜检查中对晚期肠腔和不确定的胰胆管病变的诊断准确性。

方法

这是一项对2014年1月1日至2016年12月31日接受内窥镜检查或ERCP的患者的回顾性描述性研究。其中包括被转介治疗肠腔内病变或评估不确定的胆管病变的患者。通过将标本轻轻地接触到载玻片上来制备载玻片，并在显微镜下进行检查。主要结局指标是通过将现场细胞学检查结果与相应的异位组织学诊断结果进行比较，确定ROSE-TIC的诊断准确性。

结果

所有222例患者（106例胰胆管病变和116例GI病变）均事先对肠腔腔病变进行了良性诊断，或对胰腺胆管病变的诊断不确定。ROSE-TIC的总体敏感性，特异性，阳性预测值，阴性预测值和诊断准确性分别为97％，85％，83％，97.2％和90％。准确性随活检样本的位置而异。上消化道的准确性最低，为85.2％，而下消化道病变的准确性为95％。

结论

通过建立快速的现场诊断，ROSE-TIC可以加快患者管理的决策速度。需要进行前瞻性研究以确认这些初步发现。