Ginger, a kind of foods supplement, is rich in gingerols, shogaols and paradols, possesses extensive pharmacological activities. The aim of this study was to investigate the anti-aging potential and underlying mechanisms of ginger extract (GE) in Drosophila melanogaster by detecting natural lifespan and the mRNA level of antioxidant genes, and the metabolomics approach based on UPLC-MS/MS. The W¹¹¹⁸ wild type flies were maintained on four diets containing varying amount of GE. The results showed that GE prolonged the mean and maximum lifespan of flies, and up-regulated the expression of SOD2 and CAT, down-regulated the expression of MTH, significantly. Additionally, thirteen potential biomarkers which were regulated by GE were identified. The metabolic pathway analysis suggested that GE anti-aging involved in regulating the amino acid, carbohydrate and lipid metabolism. These results indicate that the anti-aging effect of GE is achieved by protecting mitochondrial function, coordinating the oxidation-antioxidant balance and ameliorating metabolic dysfunction.

生姜是一种食品补品，富含姜油，松果油和对羟基苯甲酸酯，具有广泛的药理活性。这项研究的目的是通过检测自然寿命和抗氧化剂基因的mRNA水平，研究基于姜黄提取物（GE）在果蝇中的抗衰老潜力及其潜在机制，以及基于UPLC-MS / MS的代谢组学方法。W ¹¹¹⁸将野生型果蝇维持在含有不同数量的GE的四种日粮上。结果表明，GE延长了果蝇的平均寿命和最大寿命，并显着上调了SOD2和CAT的表达，下调了MTH的表达。另外，鉴定了由GE调节的十三种潜在生物标志物。代谢途径分析表明，GE抗衰老与调节氨基酸，碳水化合物和脂质代谢有关。这些结果表明GE的抗衰老作用是通过保护线粒体功能，协调氧化-抗氧化剂平衡和改善代谢功能障碍来实现的。