Tissue approximation and repair are conventionally performed with sutures and staples, but these means are inherently traumatic. Tissue approximation using laser‐responsive nanomaterials can lead to rapid tissue sealing and repair, and is an attractive alternative to existing clinical methods. Here, the use of laser‐activated nanosealants (LANS) with gold nanorods (GNRs) embedded in silk fibroin polypeptide matrices is demonstrated. The adaptability of LANS for sealing soft tissues is demonstrated using two different modalities: insoluble thin films for internal, intestinal tissue repair, and semisoluble pastes for external repair, shown by skin repair in live mice. Laser repaired intestinal tissue held over seven times more fluid pressure than sutured intestine and also prevented bacterial leakage. Skin incisions in mice closed using LANS' showed indication of increased mechanical strength and faster repair compared to suturing. Laser‐activated silk‐GNR nanosealants rapidly seal soft‐tissue tears and show high promise for tissue approximation and repair in trauma and routine surgery.

中文翻译：

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使用激光激活的丝纳米密封剂快速修复软组织

组织逼近和修复通常使用缝合线和订书钉进行，但这些方法本身具有创伤性。使用激光响应纳米材料的组织近似可以导致快速组织密封和修复，并且是现有临床方法的有吸引力的替代方案。在这里，展示了将激光激活的纳米密封剂 (LANS) 与嵌入丝素蛋白多肽基质中的金纳米棒 (GNR) 结合使用。LANS 用于密封软组织的适应性通过两种不同的方式得到证明：用于内部、肠组织修复的不溶性薄膜和用于外部修复的半溶性糊剂，通过活体小鼠的皮肤修复显示。激光修复的肠道组织比缝合肠道的流体压力高七倍以上，并且还可以防止细菌渗漏。使用 LANS 关闭小鼠的皮肤切口 与缝合相比，显示出机械强度增加和修复速度更快的迹象。激光激活的丝-GNR 纳米密封剂可快速密封软组织撕裂，并在创伤和常规手术中显示出组织逼近和修复的高前景。