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A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviates gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice†
Food & Function ( IF 6.1 ) Pub Date : 2018-09-04 00:00:00 , DOI: 10.1039/c8fo01174e
Shan Li 1, 2, 3, 4, 5 , Junhui Li 1, 2, 3, 4, 5 , Guizhu Mao 1, 2, 3, 4, 5 , Tiantian Wu 1, 2, 3, 4, 5 , Yaqin Hu 1, 2, 3, 4, 5 , Xingqian Ye 1, 2, 3, 4, 5 , Ding Tian 1, 2, 3, 4, 5 , Robert J. Linhardt 6, 7, 8, 9 , Shiguo Chen 1, 2, 3, 4, 5
Affiliation  

A high-fat diet (HFD) has been a major contributor to increasing morbidity caused by metabolic syndromes. Functional foods from natural sources are potential choices for addressing metabolic diseases because they provide many health benefits with a low level of adverse side effects. In our former reports, fucoidan from Pearsonothuria graeffei (fuc-Pg), a type of sulfated polysaccharides with a repeating structure, was shown to be a potential functional food ingredient. In this work, we investigated the effects of fuc-Pg on gut microbiota dysbiosis and metabolic syndromes caused by HFD. Our results indicated that fuc-Pg could reduce weight gains, alleviate hyperlipidemia, and protect the liver from steatosis in HFD-fed mice. Meanwhile, fuc-Pg decreases serum inflammatory cytokines and reduces macrophages infiltrating into adipose tissue. The gut microbiota dysbiosis caused by HFD was alleviated by administration of fuc-Pg, mainly working in the colon. Fuc-Pg increased abundances of Bacteroidetes and Actinobacteria while decreased Firmicutes and Proteobacteria. Our results indicated that fuc-Pg could be a functional food for gut microbiota dysbiosis and metabolic syndromes.

中文翻译:

从海甲岩藻依聚糖黄瓜格皮氏海参graeffei具有良好重复的结构缓和肠道微生物生态失调和代谢综合征中HFD-饲喂的小鼠

高脂饮食(HFD)一直是导致由代谢综合征引起的发病率增加的主要因素。天然来源的功能性食品是应对代谢性疾病的潜在选择,因为它们具有许多健康益处,且副作用少。在我们以前的报道,从岩藻依聚糖格皮氏海参graeffei(fuc- PG),一型包含重复结构硫酸多糖,被证明是一个潜在的功能性食品组分。在这项工作中,我们调查了fuc- Pg对HFD引起的肠道菌群失调和代谢综合征的影响。我们的结果表明,fuc- Pg可以减少高脂饮食喂养小鼠的体重增加,减轻高脂血症并保护肝脏免受脂肪变性。同时,fuc- Pg减少了血清炎性细胞因子,并减少了渗入脂肪组织的巨噬细胞。通过施用fuc- Pg减轻了由HFD引起的肠道菌群营养不良,这种作用主要在结肠中起作用。Fuc- Pg增加了拟杆菌和放线菌的丰度,同时减少了Fimicutes和Proteobacteria。我们的结果表明,fuc- Pg可能是肠道菌群失调和代谢综合征的功能性食物。
更新日期:2018-09-04
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