Hollow mesoporous silica (HMS) composed of a hollow cavity and mesoporous shell available for drug storage. The MgAl-LDH as a gatekeeper coated on the HMS outer surface by the layer-by-layer selfassembly method, encapsulated the anticancer drug 5-Fluorouracil (5-FU) within the HMS cavities and pores to get the pH-controlled drug release system (FU/[email protected]) for minimizing premature release of 5-FU. The structures, morphology, texture and 5-FU release behavior were characterized and investigated with various techniques. The kinetic data revealed that the targeted 5-FU release by the LDH-gated HMS release system (FU/[email protected]) stemmed from the dissolution of the LDH nanosheets upon decrease in pH and cleavage of the hydrogen bonds, indicating that the pH-responsive controlled release of 5-FU could be stimulated by acidic environments. These results suggested that the FU/[email protected] release system had the potential as an anticancer drug delivery system in targeted drug release for tumor chemotherapy.

空心中孔二氧化硅（HMS），由中空空腔和中孔壳组成，可用于药物存储。MgAl-LDH通过逐层自组装法在HMS外表面上涂覆作为看门人，将抗癌药物5-氟尿嘧啶（5-FU）包裹在HMS腔和孔中，从而获得pH值控制的药物释放系统（FU / [电子邮件保护]），以最大程度地减少5-FU的过早释放。用各种技术对结构，形态，质地和5-FU释放行为进行了表征和研究。动力学数据表明，LDH门控HMS释放系统（FU / [电子邮件保护]）有针对性的5-FU释放源于pH值降低和氢键断裂时LDH纳米片的溶解，表明酸性环境可以刺激5-FU的pH响应控制释放。这些结果表明，FU / [电子邮件保护]释放系统在肿瘤化学靶向药物释放中具有作为抗癌药物传递系统的潜力。