Herein, persistent luminescence nanoparticles (PLNPs) and photosensitizer are integrated for cancer theranostics with high specificity and without the need of continuous illumination. Specifically, ZnGa_1.996O₄:Cr_0.004 (PLNPs) and IR780 (photosensitizer) are encapsulated by a temperature‐responsive “wax‐seal” composed of oleic acid and hexadecanol. The seal prevents luminescence quenching and premature initiation of photodynamic therapy (PDT), until it is melted down by heat stimulus. After photothermal activation, the near‐infrared afterglow offered by PLNPs provides imaging with high signal‐to‐background ratio because of the absence of tissue autofluorescence, as well as continuously excited photosensitizer for reactive oxygen species generation. Such theranostic nanoplatform offers multimodal imaging–guided localized cancer PDT.

中文翻译：

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“蜡封”的治疗学纳米平台，用于增强余辉成像引导的光热触发光动力疗法

在此，持续发光纳米颗粒（PLNP）和光敏剂以高特异性并不需要连续照明的方式被整合用于癌症治疗学。具体而言，ZnGa _1.996 O ₄：Cr _0.004（PLNP）和IR780（光敏剂）被由油酸和十六醇组成的具有温度响应性的“蜡封”封装。该密封件可防止发光淬灭和光动力疗法（PDT）的过早启动，直到它被热刺激融化为止。光热激活后，PLNP提供的近红外余辉可以提供高信噪比的成像，因为它不存在组织自发荧光，并且可以连续激发光敏剂来产生活性氧。这样的治疗性纳米平台可提供多模态成像指导的局部癌症PDT。