Synthetic polypeptides derived from the ring-opening polymerization of N-carboxyanhydrides can spontaneously fold into stable secondary structures under specific environmental conditions. These secondary structures and their dynamic transitions play an important role in regulating the properties of polypeptides in self-assembly, catalysis, polymerization, and biomedical applications. Here, we review the current strategies to modulate the secondary structures, and highlight the conformation-specific dynamic properties of synthetic polypeptides and the corresponding materials. A number of mechanistic studies elucidating the role of secondary structures are discussed, aiming to provide insights into the new designs and applications of synthetic polypeptides. We aim for this article to bring to people's attention synthetic polymers with ordered conformations, which may exhibit association behaviors and material properties that are otherwise not found in polymers without stable secondary structures.

中文翻译：

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N-羧基酐 合成多肽中的二级结构：设计，调节，缔合和材料应用

N的开环聚合衍生的合成多肽在特定的环境条件下，-羧基酐可以自发折叠成稳定的二级结构。这些二级结构及其动态转变在自组装，催化，聚合和生物医学应用中调节多肽的性质中起着重要作用。在这里，我们综述了调节二级结构的当前策略，并突出了合成多肽和相应材料的构象特异性动态特性。讨论了许多阐明二级结构作用的机理研究，旨在为合成多肽的新设计和应用提供见识。我们的目标是使本文引起人们的注意，即具有有序构象的合成聚合物，