Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate type H vessel formation and thereby to promote osteogenesis. This study aimed to explore whether harmine, a β-carboline alkaloid, is capable of preventing bone loss in OVX mice by promoting preosteoclast PDGF-BB-induced type H vessel formation.

中文翻译：

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Harmine增强了H型血管的形成并防止了卵巢切除小鼠的骨质流失

最近，研究人员发现了一种独特的称为H型血管的血管亚型，它与血管生成和成骨作用相结合。我们先前发现在卵巢切除术（OVX）诱导的骨质疏松小鼠中H型血管减少，并且破骨细胞能够分泌血小板衍生的生长因子BB（PDGF-BB）来刺激H型血管形成，从而促进成骨作用。这项研究的目的是探讨β-咔啉生物碱是否通过促进破骨细胞PDGF-BB诱导的H型血管形成来预防OVX小鼠的骨质流失。