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Direct access to pyrrole anhydrides via oxidative self-coupling of pyrrole carboxaldehydes Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-27 Surabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K. Laha
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Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-25 Matthew Nutter, Henry Stone, Michael Shipman, Stefan Roesner
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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-26 Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
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A phosphamide nucleotide analog: a substrate for polymerase synthesis of DNA Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-22 Jiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin Ji
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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-21 Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
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A pyridine-N-oxide catenane for cation recognition Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-22 Sean R. Barlow, Nathan R. Halcovitch, Nicholas H. Evans
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Binding of the plant-derived toxin simplexin to bovine protein kinase C: insights from molecular dynamics Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-25 Yuchen Zhou, Ras Baizureen Roseli, Natasha L. Hungerford, Mary T. Fletcher, Diane Ouwerkerk, Rosalind A. Gilbert, Elizabeth H. Krenske
Pimelea poisoning of cattle is toxicologically linked to the activation of bovine protein kinase C (PKC) by the plant-derived toxin simplexin. To understand the affinity of PKC for simplexin, we performed molecular dynamics (MD) studies of simplexin, simplexin analogues, and several other activators of PKC. Binding enthalpy calculations indicated that simplexin had the strongest affinity for PKCα-C1B
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Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-20 Zhongzhen Yang, Marion Arnoux, Damien Hazelard, Owen R. Hughes, Joe Nabarro, Adrian C. Whitwood, Martin A. Fascione, Christopher D. Spicer, Philippe Compain, William P. Unsworth
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Palladium-catalyzed (Z)-selective allylation of phosphine oxides with vinylethylene carbonates to construct phosphorus allyl alcohols Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-23 Hua Huang, Yi-Qi Wu, Lu-Yao Han, Lu Jiang, Zhuo-Zhuo Zhang, Xiang Zhang, Bo Han, Wei Huang, Jun-Long Li
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Weakly acidic pH-responsive liposomal content release induced by histidine-modified agents Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-19 Ayumi Kashiwada, Narumi Taoka, Yukiha Chijimi, Keiko Noguchi, Karin Shigematsu, Motofumi Miura, Toyofumi Suzuki
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Identification and quantification of local antiaromaticity in polycyclic aromatic hydrocarbons (PAHs) based on the magnetic criterion Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-22 Erich Kleinpeter, Andreas Koch
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Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-22 Junqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian Wen
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Diversity-oriented synthesis of indole-fused scaffolds and bis(indolyl)methane from tosyl-protected tryptamine Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-21 Liang Wang, Xiaopei Song, Fengxia Guo, Lubin Xu, Fangzhi Hu, Feng-Wei Guo, Shuai-Shuai Li
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Biosynthesis of a new skyllamycin in Streptomyces nodosus: a cytochrome P450 forms an epoxide in the cinnamoyl chain Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-18 Yuhao Song, Jose A. Amaya, Vidhi C. Murarka, Hugo Mendez, Mark Hogan, Jimmy Muldoon, Paul Evans, Yannick Ortin, Steven L. Kelly, David C. Lamb, Thomas L. Poulos, Patrick Caffrey
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A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-19 Seylan Ayan, Adrian M. Rotaru, Esther G. Kaye, Gabrielle Juneau, Sunit Das, Christopher J. Wilds, Andrew A. Beharry
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Photogenerated chlorine radicals activate C(sp3)–H bonds of alkylbenzenes to access quinazolinones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-20 Xin-Yao Pan, Gui-Xia Sun, Fang-Ping Huang, Wen-Jian Qin, Qing-Hu Teng, Kai Wang
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Albumin–ruthenium catalyst conjugate for bio-orthogonal uncaging of alloc group Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-19 Kimberly S. Taylor, Madison M. McMonagle, Schaelee C. Guy, Ariana M. Human-McKinnon, Shumpei Asamizu, Heidi J. Fletcher, Bradley W. Davis, Takashi L. Suyama
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Hydrosilylation of nitriles and tertiary amides using a zinc precursor Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-18 Ravi Kumar, Rohan Kumar Meher, Himadri Karmakar, Tarun K. Panda
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Visible light-induced metal-free cascade denitrogenative borylation and iodination of nitroarenes Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-16 Jun-Wei Li, Tian-Shun Duan, Bing Sun, Fang-Lin Zhang
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Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-11 Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-15 Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-15 Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
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Phenyliodine bis(trifluoroacetate) as a sustainable reagent: exploring its significance in organic synthesis Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-15 Sumit Kumar, Aditi Arora, Sunil K. Singh, Rajesh Kumar, Bhawani Shankar, Brajendra K. Singh
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Overview of alkyl quercetin lipophenol synthesis and its protective effect against carbonyl stress involved in neurodegeneration Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-15 Léa Otaegui, Jordan Lehoux, Leo Martin, Laurent Givalois, Thierry Durand, Catherine Desrumaux, Céline Crauste
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Identification of reaction sites and chlorinated products of purine bases and nucleosides during chlorination: a computational study Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-15 Fuhao Zhang, Yonghang Mo, Xiaomin Cao, Yingying Zhou, Yong Dong Liu, Rugang Zhong
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Mutasynthesis generates nine new pyrroindomycins Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-15 Zhuhua Wu, Zhengxiang Xia, Zhijun Tang, Ji'an Li, Wen Liu
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Correction and removal of expression of concern: Total synthesis of tubulysin U and N14-desacetoxytubulysin H Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-14 Bohua Long, Cheng Tao, Yinghong Li, Xiaobin Zeng, Meiqun Cao, Zhengzhi Wu
Correction and removal of expression of concern for ‘Total synthesis of tubulysin U and N14-desacetoxytubulysin H’ by Bohua Long et al., Org. Biomol. Chem., 2020, 18, 5349–5353, https://doi.org/10.1039/D0OB01109F.
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Synthesis of difluoromethylated spiropyrazolones via [3 + 2] cycloaddition of difluoroacetohydrazonoyl bromides with alkylidene pyrazolones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-14 Yang Feng, Yuanyuan Ren, Duoduo Tang, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Xiaobo Lv, Yulai Hu
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Expression of Concern: Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-13 Zhi-Yong Tian, Song-Qiang Xie, Zi-Hou Mei, Jin Zhao, Wen-Yuan Gao, Chao-Jie Wang
Expression of Concern for ‘Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway’ by Zhi-Yong Tian et al., Org. Biomol. Chem., 2009, 7, 4651–4660, https://doi.org/10.1039/B912685F.
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Pd(II)-catalyzed cascade annulation of N-substituted anilines with CO, NH4OAc and aldehydes to N1-substituted 2,3-dihydroquinazolin-4(1H)-ones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-13 Xiaopeng Zhang, Qiuyang Pang, Dan Liu, Zhenhua Guo, Guisheng Zhang
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2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-12 Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
2-Azabicyclo[3.2.1]octanes are nitrogen containing heterocycles with significant potential in the field of drug discovery. This core has been applied as key synthetic intermediate in several total synthesis, while their unique structure can make them a challenging scaffold to acquire. This Minireview summarizes the synthetic approaches to access this bicyclic architecture and highlights its presence
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CinNapht AIE(E)gens for selective imaging of lipid droplets Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-12 Eléonore Tacke, Minh-Duc Hoang, Lilian Estaque, Philippe Durand, Grégory Pieters, Arnaud Chevalier
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Recent advances in spirocyclization of maleimides via transition-metal catalyzed C–H activation Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-11 Swadhin Swaraj Acharya, Sagarika Patra, Rojalini Maharana, Manaswini Dash, Liza Mama Barad, Bibhuti Bhusan Parida
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Iodide-umpolung catalytic system for non-traditional amide coupling from nitroalkanes and amines Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-11 Chun-Lin Chen, Tian-Sih Huang, Po-Hsiang Chang, Che-Sheng Hsu
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Catalyst-free visible light-promoted defunctionalization of alkyl isocyanides with a hydrosilane through C–N bond cleavage Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-04 Yu-Qing Ma, Shi-Kai Tian
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Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-08 Clara Bosbach, Luisa Maria Gatzemeier, Katja Ilme Bloch von Blottnitz, Annekatrin König, Ulf Diederichsen, Claudia Steinem, Tiago Fleming Outeiro
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Identification of BACE-1 inhibitors through directed C(sp3)–H activation on 5-oxo-pyrrolidine-3-carboxylic acid derivatives Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-08 Lorenzo Baldini, Elena Lenci, Cristina Faggi, Andrea Trabocchi
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Asymmetric synthesis of the fully functionalized six-membered A-ring of siphonol A Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-08 Ying Sun, Shaomin Fu, Bo Liu
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Visible-light-induced C–S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-07 Khushbu Rajput, Vishal Singh, Priya Mahaur, Sundaram Singh, Vandana Srivastava
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Design, synthesis and biological evaluation of quinazoline and pyrrolo[3,2-d]pyrimidine derivatives as TLR7 agonists for antiviral agents Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-07 Yue Song, Wenjie Fan, Chen Yao, Heng Wang, Xiuxiang Lu, Yumin Wang, Pengxiang Liu, Yanjie Ma, Zhen Zhang, Jiang Wang, BeiBei Chu, Lijun Shi, Guoyu Yang, Mengdi Wang
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DFT study on isothiourea-catalyzed C–C bond activation of cyclobutenone: the role of the catalyst and the origin of stereoselectivity Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-07 Daochang Li, Yang Wang
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Recent advances in Si-rhodamine-based fluorescent probes for live-cell imaging Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-06 Hisashi Ohno, Eita Sasaki, Sota Yamada, Kenjiro Hanaoka
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Cobalt-catalyzed amination of aziridines and azetidines toward 1,2- and 1,3-diamines Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-01 Ling-Chao Cheng, Zhihua Wang, Xinglei He, Wangfu Liang, Ke-Yin Ye
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Visible light-induced organo-photocatalyzed route to synthesize substituted pyrazoles Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-01 Koustav Pal, Vinjamuri Srinivasu, Sourabh Biswas, Devarajulu Sureshkumar
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Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-06 Hirotsugu Suzuki, Seigo Kiyobe, Takanori Matsuda
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Construction of indolizine scaffolds from α,ω-alkynoic acids and α,ω-vinylamines via sequential-relay catalysis in “one pot” Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-05 Jiami Liu, Yi Lu, Lingxuan Zhu, Xinsheng Lei
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A Ni0(cod)(dq) (COD: 1,5-cycloctadiene; DQ: duroquinone) complex as a catalyst precursor for oligothiophene and polythiophene synthesis Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-05 Naoki Noda, Seiha Yamaoka, Ukyo Ogi, Masaki Horie, Kentaro Okano, Atsunori Mori
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A visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-05 Ming Qi, An-Wu Xu
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Recent advances in the synthesis and applications of fluoranthenes Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-05 Yunus Emre Türkmen
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A visible-light-catalyzed sulfonylation reaction of an aryl selenonium salt via an electron donor–acceptor complex Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-26 Yuqing Wang, Liang Zhao, Xinyu Hao, Kun Jin, Rong Zhang, Chunying Duan, Yaming Li
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Application of the intramolecular Diels–Alder vinylarene (IMDAV) reaction for the synthesis of benzo-, carbocyclo-, thienothiopheneisoindolecarboxylic acids and its limitations Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-01 Elizaveta D. Yakovleva, Evgeniya R. Shelukho, Maryana A. Nadirova, Pavel P. Erokhin, Daria N. Simakova, Victor N. Khrustalev, Mikhail S. Grigoriev, Anton P. Novikov, Anna A. Romanycheva, Anton A. Shetnev, Olga P. Bychkova, Alexey S. Trenin, Fedor I. Zubkov, Vladimir P. Zaytsev
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Identification and quantification of N6-methyladenosine by chemical derivatization coupled with 19F NMR spectroscopy Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-01 Ting Jiang, Qian Zhou, Kang-Kang Yu, Shan-Yong Chen, Kun Li
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Reinvigorating aza-Michael reactions under ionic liquid catalysis: a greener approach Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-28 Silvia Izquierdo, Pedro Cintas, Carlos J. Durán-Valle, Juan García de la Concepción, Ignacio M. López-Coca
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I2/CF3CO2Ag-mediated iodolactonization of various allenoic acids to access versatile 6- to 9-membered ring vinylic iodolactones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-24 Xiaobo Bao, Guoli Wang, Xu Dong, Mengxiao Zhu, Lili Yang, Junjie Zhu, Qingyuan Shi, Hongzhen Zhang, Dongyin Chen
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Small-molecule fluorogenic probes based on indole scaffold Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-29 Pintu Ghosh, Anirban Karak, Ajit Kumar Mahapatra
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Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-29 Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp
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Electro-oxidative intermolecular CSP2–H amination of heteroarenes via proton-coupled electron transfer Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-29 Shuai Liu, Xin Liu, Tian-Shu Zhang, Xiaoyu Bao, Xiaoyu Sheng, Zhenjie Qi, Dongfang Jiang
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Covalently linked thieno[2,3-b]thiophene-fullerene dimers: synthesis and physical characterization Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-28 Abdulrahman M. Alazemi, Mohammad H. BinSabt, Hamad M. Al-Matar, Alan L. Balch, Mona A. Shalaby
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Copper-catalyzed oxidative cyclization of 2-(1H-pyrrol-1-yl)aniline and alkylsilyl peroxides: a route to pyrrolo[1,2-a]quinoxalines Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-24 Zhenyu An, Man Miao, Fengkai Sun, Xiao-Bing Lan, Jian-Qiang Yu, Xiaoli Guo, Jian Zhang
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Additive-assisted synthesis of α-Kdo glycosides with peracetylated glycosyl ynenoate as a donor Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-02-24 He Miao, Siqian Lu, Hongyu Chen, Jintao Shang, Jibin Zheng, You Yang