The high incidence of osteoporosis and related fractures demands for the use and development of methods capable of detecting changes in bone mechanical properties. The most common clinical and laboratory methods used to detect changes in bone mechanical properties, such as stiffness, strength, or flexural rigidity, include: mechanical testing, medical imaging, medical image-based analytical calculations, and medical image-based finite element analysis. However, the innate complexity of bone makes validation of the results from each method difficult. The current study presents the design, fabrication, and functional testing of a bi-material and computed tomography scan compatible bone-surrogate which provides consistent reproducible mechanical properties for methodological evaluation of experimental, analytical, and computational bone bending stiffness prediction methods.

骨质疏松症和相关骨折的高发率要求使用和开发能够检测骨力学性质变化的方法。用于检测骨骼机械特性（例如刚度，强度或抗弯刚度）变化的最常见临床和实验室方法包括：机械测试，医学成像，基于医学图像的分析计算和基于医学图像的有限元分析。但是，骨骼固有的复杂性使得很难验证每种方法的结果。当前的研究提出了双材料和计算机断层扫描兼容的骨替代物的设计，制造和功能测试，该替代物为实验，分析，