Self-healable hydrogels are very attractive to bioscience and biotechnology, for use in drug loading and delivery, artificial organs, and bioswitches. In this research, thermoresponsive copolymers TPE-[P(DMA-stat-DAA)]₂ containing a tetraphenylethylene (TPE) moiety and a ketone group were synthesized. The TPE unit in the middle gave the copolymer chains thermoregulated AIE properties and an LCST around body temperature. The self-healable hydrogels were prepared with a dynamic acylhydrazone bond through dihydrazide cross-linking, and the light emission properties were regulated by a thermosensitive enhanced AIE mechanism. As a result, the AIE properties were imported into the new thermoresponsive self-healable hydrogels to achieve temperature-regulated light emission properties. The in vitro cytotoxicity experiments showed that the hydrogels were biocompatible and the hydrogels showed a pH sensitive drug release profile. This kind of thermoresponsive light emission hydrogel may hold great potential for biodiagnosis, drug loading and delivery, and tissue engineering with light sensitive detection.

中文翻译：

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温度调节的聚集诱导的可自发光的自愈水凝胶，可控制药物输送†

自修复水凝胶对生物科学和生物技术非常有吸引力，可用于药物装载和输送，人工器官和生物开关。在这项研究中，合成了包含四苯基乙烯（TPE）部分和酮基的热敏共聚物TPE- [P（DMA- stat -DAA）] ₂。中间的TPE单元为共聚物链提供了可调节的AIE性能和在体温附近的LCST。通过二酰肼交联制备具有动态酰基hydr键的自修复水凝胶，并通过热敏增强的AIE机理调节其发光性能。结果，将AIE特性导入到新的热响应自修复水凝胶中，从而实现了温度可调节的发光特性。这体外细胞毒性实验表明，水凝胶具有生物相容性，并且水凝胶显示出pH敏感的药物释放曲线。这种具有热响应性的发光水凝胶在生物诊断，药物加载和输送以及具有光敏检测功能的组织工程中可能具有巨大的潜力。