Chitosan-based films with zein coatings were prepared in order to modify the drug release properties. The adhesion of zein layers to the films was ensured via a cold plasma treatment. Using ciprofloxacin hydrochloride as model, the effect of cold plasma on the functional properties and structures was evaluated. The results suggest that the encapsulation efficiency, chemical composition and crystal type of ciprofloxacin hydrochloride in chitosan/drug films were not altered by cold plasma treatment, while the wettability and surface free energy displayed a notable increase. After being coated with zein, the chitosan interacted with the zein through hydrogen bonding and electrostatic interactions. The burst release phenomenon of the chitosan/drug films was prevented by the zein coating. Furthermore, the plasma treatment provided the coated film with a slower release rate within 24 h, from 72.8% to 49.3%. The enhanced coating thickness and the more compact interface structure were responsible for this improvement.

制备具有玉米醇溶蛋白涂层的基于壳聚糖的膜以改变药物释放性能。通过冷等离子体处理确保玉米醇溶蛋白层对膜的粘附。以盐酸环丙沙​​星为模型，评价冷血浆对功能性质和结构的影响。结果表明，冷等离子体处理不会改变壳聚糖/药物膜中盐酸环丙沙​​星的包封率，化学组成和晶体类型，而润湿性和表面自由能却有明显提高。在用玉米蛋白包被后，壳聚糖通过氢键和静电相互作用与玉米蛋白相互作用。玉米醇溶蛋白涂层防止了壳聚糖/药物膜的爆裂释放现象。此外，等离子体处理使涂膜在24小时内的释放速度较慢，从72.8％降至49.3％。增加的涂层厚度和更紧凑的界面结构是这一改进的原因。