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Transcriptomic analysis reveals effects of fucoxanthin on intestinal glucose transport
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2018-08-29 , DOI: 10.1016/j.jff.2018.08.018
Wanxiu Cao , Jing Li , Yaoxian Chin , Robert W. Li , Changhu Xue , Qingjuan Tang

Fucoxanthin, one of carotenoid pigments from plants and algae, is known to regulate blood glucose and insulin levels. The mechanism of its hypoglycemic activity has drawn a lot of scientific interest in recent years. In this study, we investigated the effects of fucoxanthin on intestinal glucose transport using a murine model. Our data demonstrated that fucoxanthin was able to decrease blood glucose level and alleviate insulin resistance significantly. The results from RNA-seq based transcriptomic analysis, suggested that fucoxanthin acted as a key regulator in Insulin/PI3K/AKT/mTOR signaling and PKA/AMPK/mTOR signaling pathways. Moreover, fucoxanthin ingestion resulted in a significant reduction in the protein expression of intestinal glucose transporters, such as SGLT-1, and led to decreased translocation of GLUT-2, which contributed to the regulation of blood glucose level. Together, our findings provided a mechanistic insight into the regulatory effect of fucoxanthin on blood glucose.



中文翻译:

转录组学分析显示了岩藻黄质对肠道葡萄糖转运的影响

岩藻黄质,一种来自植物和藻类的类胡萝卜素色素,已知可以调节血糖和胰岛素水平。近年来,其降血糖活性的机制引起了许多科学兴趣。在这项研究中,我们使用鼠模型研究了岩藻黄质对肠道葡萄糖转运的影响。我们的数据表明岩藻黄质能够降低血糖水平并显着减轻胰岛素抵抗。基于RNA-seq的转录组分析结果表明,岩藻黄质在胰岛素/ PI3K / AKT / mTOR信号转导和PKA / AMPK / mTOR信号转导通路中起关键调节剂的作用。此外,岩藻黄质的摄入会导致肠道葡萄糖转运蛋白(例如SGLT-1)的蛋白质表达显着降低,并导致GLUT-2的转运降低,这有助于调节血糖水平。在一起,我们的发现为岩藻黄质对血糖的调节作用提供了机械的见解。

更新日期:2018-08-29
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