Enantioselective synthesis of axially chiral vinyl arenes through palladium-catalyzed C–H olefination†,Chemical Communications

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Enantioselective synthesis of axially chiral vinyl arenes through palladium-catalyzed C–H olefination†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-08-29 00:00:00 , DOI: 10.1039/c8cc05555f
Qiao-Ying Sun _{1,

2,

3,

4} , Wei-Yang Ma _{1,

2,

3,

4} , Ke-Fang Yang _{1,

2,

3,

4} , Jian Cao _{1,

2,

3,

4} , Zhan-Jiang Zheng _{1,

2,

3,

4} , Zheng Xu _{1,

2,

3,

4} , Yu-Ming Cui _{1,

2,

3,

4} , Li-Wen Xu _{1,

2,

3,

4}

Affiliation

A palladium-catalyzed ketoxime-chelation-assisted enantioselective C–H olefination of 2-arylcyclohex-2-enone oxime ether with a wide range of olefins as coupling partners was developed. Employing ketoxime ether as an efficient directing group, a variety of axially chiral vinyl arenes was synthesized by Pd(II)-catalyzed C–H functionalization with excellent enantioselectivities (96 → 99% ee) under mild conditions.

中文翻译：

通过钯催化的CH-H烯化反应，对映选择性地合成轴向手性乙烯基芳烃†

开发了钯催化的酮肟肟螯合辅助的2-芳基环己-2-烯酮肟醚的对映选择性C-H烯烃化反应，该反应中使用了多种烯烃作为偶联伙伴。利用酮肟醚作为有效的导向基团，在温和的条件下，通过Pd（II）催化的C–H官能化，具有优异的对映选择性（96→99％ee），合成了多种轴向手性乙烯基芳烃。

更新日期：2018-08-29

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