A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded compounds with improved potency, kinase selectivity and good in vitro ADME properties. These compounds could be useful tools in the development of new anti-malarial drugs in the fight against drug resistant malaria.

中文翻译：

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三取代噻唑作为恶性疟原虫蛋白激酶 G (PfPKG) 的有效和选择性抑制剂

通过从已知的艾美球虫PKG ( Et PKG) 抑制剂中进行模板跳跃，一系列三取代噻唑已被鉴定为恶性疟原虫 (Pf) cGMP 依赖性蛋白激酶 ( Pf PKG) 的有效抑制剂。噻唑系列产生的化合物具有改进的效力、激酶选择性和良好的体外ADME 特性。这些化合物可能是开发新的抗疟疾药物以对抗耐药性疟疾的有用工具。