Epidemiological studies have shown that coffee consumption may be associated with a lower risk of developing several neurological disorders, including Alzheimer's disease (AD). Caffeine is a prominent candidate component underlying the preventive effects of coffee; however, the contribution of other constituents is unclear. To clarify this issue, the effect of roasting coffee beans on β‐secretase (BACE1) expression in human neuroblastoma SH‐SY5Y cells is investigated.

中文翻译：

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烘焙咖啡通过增加人类神经母细胞瘤SH-SY5Y细胞中的蛋白酶体β-分泌酶降解来减少β-淀粉样蛋白的产生

流行病学研究表明，喝咖啡与患多种神经系统疾病（包括阿尔茨海默氏病（AD））的风险较低相关。咖啡因是咖啡预防作用的重要候选成分。但是，其他选民的贡献尚不清楚。为了澄清这个问题，研究了烘焙咖啡豆对人神经母细胞瘤SH-SY5Y细胞中β-分泌酶（BACE1）表达的影响。